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COMPOUNDS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISORDERS ON THE OLFACTORY EPITHELIUM

机译：诊断嗅上皮神经退行性疾病的化合物

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摘要

The present invention relates to compounds having a high affinity for the Aβ protein, α-synuclein or for Tau-PHF aggregates, which are suitable as preferably fluorescent probes for the in-vivo diagnosis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The compounds are distinguished by suitable physiochemical properties (excitation wavelength, emission wavelength, Stokes shift, extinction) and also high affinity and selectivity for the target proteins.

机译：本发明涉及对Aβ蛋白，α-突触核蛋白或Tau-PHF聚集体具有高亲和力的化合物，其适合作为优选荧光探针用于体内诊断神经退行性疾病，例如阿尔茨海默氏病和帕金森氏病。这些化合物的特征在于合适的理化特性（激发波长，发射波长，斯托克斯位移，消光）以及对靶蛋白的高亲和力和选择性。

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公开/公告号WO2012037928A3

专利类型
公开/公告日2013-04-25

原文格式PDF
申请/专利权人 KLINIKUM DARMSTADT GMBH;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;TECHNISCHE UNIVERSITAET DARMSTADT;SCHMIDT BORIS;KIESER DANIEL;BOLAENDER ALEXANDER;HERMS JOCHEN;HEYNY-VON HAUSSEN ROLAND HANS;GU JIAMIN;
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申请/专利号WO2011DE01780
发明设计人 HEYNY-VON HAUSSEN ROLAND HANS;HERMS JOCHEN;BOLAENDER ALEXANDER;SCHMIDT BORIS;KIESER DANIEL;GU JIAMIN;
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申请日2011-09-20
分类号G01N33/68;A61K31/33;C07D211/00;C07D403/00;C07D417/00;A61K49/00;
国家 WO
入库时间 2022-08-21 16:36:59

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