METHODS FOR CHARACTERIZING VAGINAL TISSUE ELASTICITY AND ASSESSMENT OF PELVIC ORGAN CONDITIONS AFFECTING THE VAGINA

• 1. 盆腔器官脱垂定量分度阴道窥器 [P] . 中国专利： CN205913326U . 2017.02.01
• 2. 一种用于妇科阴道保洁、保健并治疗妇科阴道疾病的外用药剂及其制备方法 [P] . 中国专利： CN111840521A . 2020-10-30
• 3. METHODS FOR CHARACTERIZING VAGINAL TISSUE ELASTICITY AND ASSESSMENT OF PELVIC ORGAN CONDITIONS AFFECTING THE VAGINA [P] . 欧洲知识产权局专利： EP2611360A2 . 2013-07-10

  机译： 表征阴道组织弹性和影响阴道的盆腔器官疾病的方法

• 4. METHODS FOR CHARACTERIZING VAGINAL TISSUE ELASTICITY AND ASSESSMENT OF PELVIC ORGAN CONDITIONS AFFECTING THE VAGINA [P] . 世界知识产权组织专利： WO2012031235A2 . 2012-03-08

  机译： 表征阴道组织弹性和影响阴道的盆腔器官疾病的方法

• 5. Methods for assessment of pelvic organ conditions affecting the vagina [P] . 美国专利： US8187208B2 . 2012-05-29

  机译： 评估影响阴道的盆腔器官状况的方法

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• 8. Protocol for a randomized controlled trial to assess two procedures of vaginal native tissue repair for pelvic organ prolapse at the time of the questioning on vaginal prosthesis: the TAPP trial [O] . A. Lacorre, F. Vidal, S. Campagne-Loiseau, 2020

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• 4. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
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