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Immunising against meningococcal serogroup Y using proteins

机译:使用蛋白质免疫针对脑膜炎球菌血清群Y

摘要

#$%^&*AU2011204789B220130711.pdf#####ABSTRACT The established dogma for meningococcus is thus that immunisation against serogroups A, C, W135 and Y shall be based on the four different capsular saccharides, and that immunisation against serogroup B shall not be based on the capsular saccharide. In contrast, the invention uses polypeptide antigens and/or OMVs to immunise against serogroups A, C, W135 and Y (and against serogroup Y in particular). Serogroup B polypeptides can achieve this protection, thus permitting a single polypeptide-based vaccine to be used for protecting against all of serogroups A, B, C, W 135 and Y.
机译:#$%^&* AU2011204789B220130711.pdf #####抽象因此,已确定的脑膜炎球菌教条是针对血清群A,C,W135和Y应基于四种不同的荚膜糖,并进行免疫针对血清群B的抗药性不应基于荚膜糖。相反,本发明使用多肽抗原和/或OMV免疫血清群A,C,W135和Y(尤其是针对血清群Y)。血清群B多肽可以实现这种保护,因此,允许使用单一的基于多肽的疫苗来预防所有血清群A,B,C,W 135和Y.

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