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METHOD FOR EVALUATION OF EFFECTIVENESS OF TREATMENT OF DIABETIC NEPHROPATHY

机译：评价糖尿病性肾病治疗效果的方法

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Method for evaluation of effectiveness of treatment of diabetic nephropathy includes evaluation of decrease of the levels of micro-albuminuria, proteinuria, rate of glomerular filtration before and after treatment course. One determines the levels of interleukin -1, interleukin-10, gamma-interferon and transforming growth factor in blood serum of patients in dynamics of treatment. One calculates the ratio of gamma-interferon/interleukin-10 as characteristic of immune-inflammatory activity. If the levels of interleukin -1, gamma-interferon and transforming growth factor are decreased 1.5 times and more compared to initial level, or come to control values, and the level of interleukin-10 increases and the ratio gamma-interferon/ interleukin-10 decreases to control values, treatment is evaluated as effective. At absence of change of the levels of activity of those ferments after the course of treatment or at presence of negative dynamics of those treatment is evaluated as non-effective.

机译：评估糖尿病肾病治疗效果的方法包括评估治疗过程前后微量白蛋白尿，蛋白尿，肾小球滤过率的降低。在动态治疗中，可以确定患者血清中白介素-1，白介素-10，γ-干扰素和转化生长因子的水平。人们计算出γ-干扰素/白介素10的比例作为免疫炎症活性的特征。如果白细胞介素-1，γ-干扰素和转化生长因子的水平比初始水平降低1.5倍或更多，或者达到控制值，则白细胞介素10的水平增加并且γ-干扰素/白细胞介素10的比率如果降低至控制值，则治疗被视为有效。在治疗过程之后，在那些发酵物的活性水平没有变化的情况下，或者在那些治疗的负面动态的存在下，被认为是无效的。

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公开/公告号UA77283U

专利类型
公开/公告日2013-02-11

原文格式PDF
申请/专利权人 INSTITUTE OF NEPHROLOGY OF THE NAMS OF UKRAINE STATE INSTITUTION;
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申请/专利号UAU201208316U
发明设计人 DUDAR IRYNA OLEKSIIVNA;LOBODA OLENA MYKOLAIVNA;DRIYANSKA VIKTORIIA YEVHENIVNA;POROSHYNA TETYANA VIKTORIVNA;MARYNENKO MYKOLA IVANOVYCH;KRASIUK EDUARD KOSTIANTYNOVYCH;KROT VIKTOR FEDOROVYCH;
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申请日2012-07-06
分类号G01N33/53;A61P13/12;
国家 UA
入库时间 2022-08-21 16:39:54

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