首页> 外国专利> The new method (platform) for finding biologically active molecules, to assess the quality of cells for cells therapy and to control the quality of production of recombinant proteins based on the analysis of mobility of intracellular organelles in conjunction with medical conditions

The new method (platform) for finding biologically active molecules, to assess the quality of cells for cells therapy and to control the quality of production of recombinant proteins based on the analysis of mobility of intracellular organelles in conjunction with medical conditions

机译：一种新的方法（平台），该方法可根据细胞内细胞器的流动性以及医疗条件分析发现具有生物活性的分子，评估用于细胞治疗的细胞的质量并控制重组蛋白的生产质量

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摘要

The present invention provides a platform that incorporates in vitro cell systems, methods and standard for manipulating and / or analyzing intracellular mobility of cell organelles, important for understanding the underlying cellular processes as well as for the use of cells for medical and biotechnological purposes. The novelty of the present invention is a combination of approaches comprising: i) a method for monitoring the dynamics within cellular organelles to search for biologically active substances (eg, components of sera, cerebrospinal fluid, and other biologically active inorganic or organic molecules and mixtures thereof), ii) a method for determining cell quality for advanced cell therapies; and iii) a method for evaluating and controlling the quality of production of recombinant proteins within eukaryotic cells in relation to intra-organelle mobility. The present invention also provides a basis for studying the effects of various pharmaceutical agents for the treatment / modulation of certain pathological conditions affecting intercellular communication and the related mobility and dynamics within cellular organelles.

机译：本发明提供了平台，该平台结合了用于操纵和/或分析细胞器的细胞内移动性的体外细胞系统，方法和标准，这对于理解潜在的细胞过程以及将细胞用于医学和生物技术目的是重要的。本发明的新颖性是多种方法的组合，包括：i）监测细胞器内动态的方法，以寻找生物活性物质（例如，血清，脑脊液的成分以及其他生物活性无机或有机分子及其混合物） ii）确定高级细胞疗法的细胞质量的方法; iii）一种评估和控制与细胞内迁移有关的真核细胞内重组蛋白生产质量的方法。本发明还提供了研究各种药物对治疗/调节某些影响细胞间通讯以及细胞器内相关迁移和动态的病理状况的作用的基础。

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公开/公告号SI23811A

专利类型
公开/公告日2013-01-31

原文格式PDF
申请/专利权人 UNIVERZA V LJUBLJANI;CELICA D.O.O.;CENTER ODLICNOSTI ZA INTEGRIRANE PRISTOPE V KEMIJI IN BIOLOGIJI PROTEINOV (CIPKEBIP);
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申请/专利号SI20110000250
发明设计人 ROBERT ZOREC;MATJAZ STENOVEC;SASA TRKOV;NINA VARDJAN;MAJA POTOKAR;MARKO KREFT;MATEJA GABRIJEL;JERNEJ JORGACEVSKI;
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申请日2011-07-11
分类号G01N1;G01N21;
国家 SI
入库时间 2022-08-21 16:40:00

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