首页> 外国专利> USE OF ANTI THIRD PARTY CENTRAL MEMORY T CELLS FOR ANTI-LEUKEMIA/LYMPHOMA TREATMENT.

USE OF ANTI THIRD PARTY CENTRAL MEMORY T CELLS FOR ANTI-LEUKEMIA/LYMPHOMA TREATMENT.

机译:抗第三方白血病/淋巴瘤的治疗中使用的第三方抗体。

摘要

A method of treating a disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting a non-syngeneic cell or tissue graft to the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of cells comprising non-graft versus host (GVHD) inducing anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, and further wherein the cells are either: (i) non-syngeneic with both the subject and the graft; or (ii) non-syngeneic with the graft and syngeneic with the subject, thereby treating the subject.
机译:公开了一种在有需要的受试者中治疗疾病的方法。该方法包括:(a)将非同基因的细胞或组织移植物移植到受试者; (b)向受试者施用治疗有效量的分离的细胞群,其包含具有中枢记忆T淋巴细胞(Tcm)表型的非移植物抗宿主(GVHD)诱导抗第三方细胞,该细胞为耐受性-诱导细胞并且能够在移植后归巢到淋巴结,并且进一步地其中细胞是:(i)与受试者和移植物均非同基因的; (ii)与移植物非同系而与受试者同系,从而治疗受试者。

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