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Oral transmucosal composition, a method of enhancing transmucosal absorption of a biologically active polypeptide, a method of administering a biologically active polypeptide to a non-human recipient, a solid oral dosage form for transmucosal absorption and use of an oral transmucosal composition in the preparation of a medicament
Oral transmucosal composition, a method of enhancing transmucosal absorption of a biologically active polypeptide, a method of administering a biologically active polypeptide to a non-human recipient, a solid oral dosage form for transmucosal absorption and use of an oral transmucosal composition in the preparation of a medicament
The invention described herein provides an oral solid transmucosal dosage form that enhances transmucosal permeation of biologically active polypeptides across oral mucosal tissue and provides relatively rapid efficacious therapeutic onset thereof. Dosage forms prepared according to the invention can enhance transmucosal absorption of polypeptides in therapeutic serum concentrations to the recipient. The invention provides a solid dosage form for oral transmucosal absorption of a biologically active polypeptide, wherein the dosage form comprises a pharmaceutical composition comprising: a therapeutically active polypeptide; a bile sa and an effervescent excipient component, which can comprise an effervescent couple and optionally a pH adjusting substance.; The invention includes a method of administering a biologically active polypeptide, as well as a method of enhancing transmucosal absorption of a biologically active polypeptide.
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