首页> 外国专利> Composition comprising biologically active ifn--beta and highly purified mannitol, a method of producing a formulation of biologically active ifn-beta having improved stability and a method for increasing the stability of biologically active ifn-beta in a composition

Composition comprising biologically active ifn--beta and highly purified mannitol, a method of producing a formulation of biologically active ifn-beta having improved stability and a method for increasing the stability of biologically active ifn-beta in a composition

机译：包含生物活性的ifn-β和高度纯化的甘露醇的组合物，制备具有改善的稳定性的生物活性的ifn-β的制剂的方法以及增加组合物中生物活性的ifn-β的稳定性的方法

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摘要

Stabilized pharmaceutical formulations comprising IFN-beta and highly purified mannitol are provided. The highly purified mannitol stabilizes the compositions by reducing the formation of IFN-beta adducts in comparison with IFN-beta formulated with mannitol that has not been highly purified. Methods for increasing the stability of IFN-beta or a variant thereof in a liquid or lyophilized composition and for increasing storage stability of such a composition are also provided.

机译：提供了包含IFN-β和高度纯化的甘露醇的稳定的药物制剂。与未高度纯化的甘露醇配制的IFN-β相比，高度纯化的甘露醇通过减少IFN-β加合物的形成来稳定组合物。还提供了用于增加在液体或冻干的组合物中的IFN-β或其变体的稳定性以及用于增加这种组合物的储存稳定性的方法。

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公开/公告号IL155788A

专利类型
公开/公告日2013-09-30

原文格式PDF
申请/专利权人 NOVARTIS VACCINES AND DIAGNOSTICS INC.;
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申请/专利号IL20030155788
发明设计人
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申请日2003-05-06
分类号A61K;A61M5/28;A61K9;A61K9/08;A61K9/19;A61K38;A61K38/21;A61K47/02;A61K47/26;A61K47/42;
国家 IL
入库时间 2022-08-21 16:41:36

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