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METHODS OF TREATING MULTIPLE MYELOMA AND MYELOMA-INDUCED BONE RESORPTION USING INTEGRIN ANTAGONISTS

机译：整合素拮抗剂治疗多发性骨髓瘤和骨髓诱导骨再吸收的方法

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摘要

Antagonists of alpha4 integrin/alpha4 integrin ligand adhesion, which inhibit the biological effects of such adhesion are described and methods for their use are detailed. Such antagonists are useful in suppressing bone destruction associated with multiple myeloma. The homing of multiple myeloma cells to bone marrow and their alpha4 integrin-dependent release of bone-resorbing factors, resulting in bone destruction in patients with multiple myeloma, is inhibited.

机译：描述了抑制这种粘附的生物学效应的α4整联蛋白/α4整联蛋白配体粘附的拮抗剂，并详细说明了其使用方法。这样的拮抗剂可用于抑制与多发性骨髓瘤有关的骨破坏。抑制了多发性骨髓瘤细胞向骨髓的归巢以及它们的α4整合素依赖性骨吸收因子的释放，导致多发性骨髓瘤患者的骨质破坏。

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公开/公告号HU229038B1

专利类型
公开/公告日2013-07-29

原文格式PDF
申请/专利权人 BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM;
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申请/专利号HU20010003630
发明设计人 MUNDY GREGORY R.;YONEDA TOSHIYUKI;
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申请日1999-09-13
分类号A61K38/17;C12N15/09;A61K38;A61K39/395;A61K45;A61P19;A61P35;C07K14/705;C07K16/18;C07K16/28;
国家 HU
入库时间 2022-08-21 16:41:40

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