首页> 外国专利> Method to treat, prevent, or mitigate Contrast induced nephropathy comprising administering a compound inhibitor of neutral Endopeptidase and selected candoxatril dexecadotril, among others, and Biphenyl substituted Compounds, and the use of these compounds to treat, prevent, or m The itigar nephropathy.

Method to treat, prevent, or mitigate Contrast induced nephropathy comprising administering a compound inhibitor of neutral Endopeptidase and selected candoxatril dexecadotril, among others, and Biphenyl substituted Compounds, and the use of these compounds to treat, prevent, or m The itigar nephropathy.

机译：治疗，预防或减轻对比剂诱发的肾病的方法，包括给予中性内肽酶和选择的坎地沙特韦龙胆三醇等化合物抑制剂和联苯取代的化合物，以及这些化合物在治疗，预防或预防类卡因性肾病中的用途。

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摘要

The present invention provides the use of a neutral endopeptidase inhibitor, in the manufacture of a medicament for the treatment, amelioration and/or prevention of contrast-induced nephropathy. The invention also relates to the use of a compound of Formula I: wherein R1, R2, R3, R5, X, A3, B1, s and n are defined herein, for the treatment, amelioration and/or prevention of contrast-induced nephropathy. The present invention further provides a combination of pharmacologically active agents for use in the treatment, amelioration and/or prevention of contrast-induced nephropathy.

机译：本发明提供了中性内肽酶抑制剂在制备用于治疗，改善和/或预防造影剂诱发的肾病的药物中的用途。本发明还涉及式I的化合物在治疗，改善和/或预防造影剂诱发的肾病中的用途，其中本文定义了R1，R2，R3，R5，X，A3，B1，s和n。。本发明进一步提供了用于治疗，改善和/或预防造影剂诱发的肾病的药理活性剂的组合。

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公开/公告号CL2013001383A1

专利类型
公开/公告日2013-10-04

原文格式PDF
申请/专利权人 NOVARTIS AG.;
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申请/专利号CL20130001383
发明设计人 SHI YIN FOO;
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申请日2013-05-15
分类号A61K31/341;A61P13/12;
国家 CL
入库时间 2022-08-21 16:42:07

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