首页> 外国专利> Isoindol - amide Compounds, pirrolo pyridin - - - - pirrolo pirimimidin amide and amide inhibitors nampt and rock; Pharmaceutical Composition and Method for treating hiperetension,;Chronic Heart Failure, atherosclerosis, Asthma, Alzheimer's disease, Parkinson's disease and glaucoma, among other diseases.

Isoindol - amide Compounds, pirrolo pyridin - - - - pirrolo pirimimidin amide and amide inhibitors nampt and rock; Pharmaceutical Composition and Method for treating hiperetension,;Chronic Heart Failure, atherosclerosis, Asthma, Alzheimer's disease, Parkinson's disease and glaucoma, among other diseases.

机译：isoindol-酰胺化合物，吡咯并吡啶酮-吡咯并嘧啶丁酰胺和酰胺抑制剂，安非他命和岩石;用于治疗高血压，慢性心力衰竭，动脉粥样硬化，哮喘，阿尔茨海默氏病，帕金森氏病和青光眼以及其他疾病的药物组合物和方法。

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摘要

Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of using the compounds to treat diseases during which NAMPT is expressed, e.g., cancer, metabolic disorders, and inflammatory disorders. Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of using the compounds to treat diseases during which ROCK is expressed, e.g., cancer, cardiovascular disorders, and inflammatory disorders.

机译：公开了抑制NAMPT活性的1，3-二氢-2H-异吲哚化合物，包含该化合物的组合物以及使用该化合物治疗表达NAMPT的疾病例如癌症，代谢疾病和炎性疾病的方法。公开了抑制ROCK活性的1，3-二氢-2H-异吲哚化合物，包含该化合物的组合物和使用该化合物治疗表达ROCK的疾病例如癌症，心血管疾病和炎性疾病的方法。

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公开/公告号CL2013001340A1

专利类型
公开/公告日2013-09-06

原文格式PDF
申请/专利权人 1) ABBVIE INC.2) ABBVIE DEUTSCHLAND GMBH & CO. KG.;
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申请/专利号CL20130001340
发明设计人 CURTIN MICHAEL L.;SORENSE BRYAN K.;HEYMAN HOWARD R.;CLARK RICHARD F.;WOLLER KEVIN R.;SHAH OMAR J;MICHAELIDES MICHAEL L.;TSE CHRIS;VASUDEVAN ANIL;MACK HELMUT;HANSEN TODD M.;SWIES RAMZI;PLIUSHCHEV MARINA A.;
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申请日2013-05-14
分类号C07D209/44;A61K31/4035;A61P1/00;A61P1/04;A61P11/06;A61P13/10;A61P15/10;A61P17/06;A61P19/02;A61P19/10;A61P25/04;A61P25/08;A61P25/16;A61P25/18;A61P25/24;A61P25/28;A61P27/00;A61P27/06;A61P29/00;A61P3/08;A61P3/10;A61P31/04;A61P31/12;A61P31/18;A61P35/00;A61P35/02;A61P35/04;A61P37/06;A61P9/10;A61P9/12;
国家 CL
入库时间 2022-08-21 16:42:07

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