首页> 外国专利> Pirazin compounds cabonil imino 2 - - - - - 1,3,8 triaza spiro 4.Deccan - 5 - substituted,Blockers of the epithelial sodium channel (ENAC); Pharmaceutical composition that includes; method of prevention or treatment; and its use to treat a disease or condition mediated by blockingThe epithelial sodium channel.

Pirazin compounds cabonil imino 2 - - - - - 1,3,8 triaza spiro 4.Deccan - 5 - substituted,Blockers of the epithelial sodium channel (ENAC); Pharmaceutical composition that includes; method of prevention or treatment; and its use to treat a disease or condition mediated by blockingThe epithelial sodium channel.

机译：吡嗪化合物卡波尼尔亚氨基2----1,3,8 triaza spiro [4.Deccan]-5-取代，上皮钠通道阻滞剂（ENAC）;药物组合物包括;预防或治疗方法;及其用于治疗由阻断上皮钠通道介导的疾病或病症的用途。

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摘要

Compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, are useful for treating diseases mediated by blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

机译：式I化合物及其药学上可接受的盐和溶剂化物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9和R10具有说明书中所述的含义，可用于治疗由以下药物介导的疾病阻断上皮钠通道。还描述了包含所述化合物的药物组合物和制备所述化合物的方法。

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公开/公告号CL2013000713A1

专利类型
公开/公告日2013-08-09

原文格式PDF
申请/专利权人 NOVARTIS AG;
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申请/专利号CL20130000713
发明设计人 BHALAY GURDIP;EDWARDS LEE;HOWSHAM CATHERINE;HUNT PETER;SMITH NICHOLA;
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申请日2013-03-15
分类号C07D487/10;A61K31/497;A61P11/00;
国家 CL
入库时间 2022-08-21 16:42:09

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