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Compounds and methods for PKC theta inhibition

机译:抑制PKC theta的化合物和方法

摘要

The present invention provides a method of selectively inhibiting PKCθ in the presence of PKCδ, by administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I. The present invention also provides a method of inhibiting cytokine synthesis in a T cell, a method of inhibiting T cell proliferation, and a method of inhibiting the replication of and cytokine production by T lymphocytes, while not stimulating or inhibiting the replication of B lymphocytes.
机译:本发明提供了一种通过在有需要的受试者中施用治疗有效量的式I化合物来选择性抑制PKCδ的方法,该方法可抑制T细胞中细胞因子的合成。细胞,抑制T细胞增殖的方法,以及抑制T淋巴细胞的复制和由其产生细胞因子的方法,而不刺激或抑制B淋巴细胞的复制。

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