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Matrix for real-time aerosol mass spectrometry of atmospheric aerosols and real-time aerosol MALDI MS method

机译：大气气溶胶实时气溶胶质谱分析矩阵和实时气溶胶MALDI MS方法

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摘要

The invention is directed to a matrix material for MALDI mass spectrometry, to a matrix composition for MALDI mass spectrometry, in particular for aerosol MALDI mass spectrometry, to a MALDI mass spectrometry method, in particular an aerosol MALDI mass spectrometry method, to the use of a specific compound as a MALDI matrix material, and to the use of a MALDI matrix composition in a gas phase coating method. The matrix material of the invention comprises a 2-mercapto-4,5-dialkylthiazole according to formula (I), wherein X is chosen from S, O or N, and wherein R1 and R2 are independently chosen from hydrogen, methyl, methoxy, ethoxy, and propoxy, or wherein R1 and R2 are taken together to form an optionally substituted aromatic ring structure, optionally comprising one or more heteroatoms, or a tautomeric form thereof. A matrix composition preferably includes the matrix material and an alcohol. The alcohol can be halogenated. The MALDI MS method comprises contacting the analyte with the matrix material or the matrix composition; ionising at least part of the analyte, and separating the ionised components using a mass spectrometer, e.g. TOF-MS. Preferably, bioaerosols are contacted with the matrix material in the gas phase.; embedded image
机译：本发明涉及用于MALDI质谱的基质材料，用于MALDI质谱的基质组合物，特别是用于气溶胶MALDI质谱的基质组合物，MALDI质谱方法，特别是气溶胶MALDI质谱方法，以及特定化合物作为MALDI基质材料，以及MALDI基质组合物在气相涂覆方法中的用途。本发明的基质材料包含根据式（I）的2-巯基-4,5-二烷基噻唑，其中X选自S，O或N，并且其中R 1 和R 2 独立地选自氢，甲基，甲氧基，乙氧基和丙氧基，或其中R 1 和R 2 一起形成任选取代的芳环结构，任选包含一个或多个杂原子，或其互变异构形式。基质组合物优选包含基质材料和醇。醇可以被卤化。 MALDI MS方法包括使分析物与基质材料或基质组合物接触。将至少一部分分析物电离，并使用质谱仪（例如质谱仪）分离电离的组分。 TOF-MS。优选地，生物气溶胶在气相中与基质材料接触。 “嵌入式图像”

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