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Process for the production of the Actinobacillus pleuropneumoniae toxins APXI or APXIII in a liquid culture medium under supply of air enriched in carbon dioxide
Process for the production of the Actinobacillus pleuropneumoniae toxins APXI or APXIII in a liquid culture medium under supply of air enriched in carbon dioxide
The current invention pertains to a method to produce RTX-toxins ApxI or ApxIII by culturing Actinobacillus pleuropneumoniae bacteria in a liquid culturing medium that supports growth of the bacteria, characterized in that air is passed through the medium, wherein the air has a carbon dioxide content above normal atmospheric level to increase RTX-toxin production during the production phase of the RTX-toxins.
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