Method of diagnosing the presence and/or severity of a hepatic pathology in an individual and/or of monitoring the effectiveness of a treatment for one such pathology

• 1. 诊断个体中肝脏病理的存在和/或严重性和/或监控这种病理的治疗有效性的方法 [P] . 中国专利： CN1985259A . 2007-06-20
• 2. SjHSP60在制备监测血吸虫病患者综合肝脏病理损伤程度的诊断试剂中的应用 [P] . 中国专利： CN103063846B . 2014.08.13
• 3. METHOD OF DIAGNOSING THE PRESENCE AND/OR SEVERITY OF A HEPATIC PATHOLOGY IN AN INDIVIDUAL AND/OR OF MONITORING THE EFFECTIVENESS OF A TREATMENT FOR ONE SUCH PATHOLOGY [P] . 美国专利： US2014011211A1 . 2014-01-09

  机译： 诊断个人和/或监测一种这类病理的治疗效果的肝病理的存在和/或严重性的方法

• 4. METHOD OF DIAGNOSING THE PRESENCE AND/OR SEVERITY OF A HEPATIC PATHOLOGY IN AN INDIVIDUAL AND/OR OF MONITORING THE EFFECTIVENESS OF A TREATMENT FOR ONE SUCH PATHOLOGY [P] . 欧洲知识产权局专利： EP1745403B1 . 2014-01-01

  机译： 诊断个人和/或监测一种这类病理的治疗效果的肝病理的存在和/或严重性的方法

• 5. Method of Diagnosing the Presence and/or Severity of a Hepatic Pathology in an Individual and/or of Monitoring the Effectiveness of a Treatment for one such Pathology [P] . 美国专利： US2009143993A1 . 2009-06-04

  机译： 诊断个体中肝病理的存在和/或严重性和/或监测一种此类病理的治疗效果的方法

• 1. Erratum: Consensus statement on effective communication of urgent diagnoses and significant, unexpected diagnoses in surgical pathology and cytopathology from the College of American Pathologists and Association of Directors of Anatomic and Surgical Pathology (Archives of Pathology and Laboratory Medicine (2012) 136:2 (148-154)) [J] . NakhlehR.E., MyersJ.L., AllenT.C. Archives of pathology & laboratory medicine . 2012,第4期
• 2. The relationship between psychopathology symptom clusters and the presence of comorbid psychopathology in individuals with severe to profound intellectual disability. [J] . Kozlowski AM, Matson JL, Sipes M, Research in developmental disabilities . 2011,第5期
• 3. Consensus statement on effective communication of urgent diagnoses and significant, unexpected diagnoses in surgical pathology and cytopathology from the college of American pathologists and association of directors of anatomic and surgical pathology [J] . NakhlehR.E., MyersJ.L., AllenT.C., Archives of pathology & laboratory medicine . 2012,第2期
• 4. Improving the Methods for Visualization of Middle Ear Pathologies Based on Telemedicine Services in Remote Treatment [C] . Oleg Avrunin, Kostyantyn Kolisnyk, Yana Nosova, IEEE KhPI Week on Advanced Technology Conference . 2020
• 5. TEST PERFORMANCE OF PSYCHOTIC CHILDREN WITH ORGANIC BRAIN PATHOLOGY: A STUDY TO DETERMINE WHETHER THE BENDER-GESTALT TEST, THE BENTON VISUAL RETENTION TEST, AND THE MARBLE BOARD TEST CAN DETECT THE PRESENCE OF ORGANIC BRAIN PATHOLOGY IN PSYCHOTIC CHILDREN. [D] . MATUNAS, MARIAN ISABEL. 1960
• 6. Monitoring the Effect of Docetaxel Treatment in MCF7 Xenografts Using Multimodal In Vivo and Ex Vivo Magnetic Resonance Methods Histopathology and Gene Expression [O] . Else Marie Huuse, Line Rørstad Jensen, Pål Erik Goa, 2010
• 7. Monitoring the Effect of Docetaxel Treatment in MCF7 Xenografts Using Multimodal In Vivo and Ex Vivo Magnetic Resonance Methods, Histopathology, and Gene Expression1 [O] . Huuse, Else Marie, Jensen, Line Rørstad, Goa, Pål Erik, 2010

• 1. Application of Optical Methods in Blood Studies upon Evaluation of Severity Rate of Diffuse Liver Pathology [J] . Margarita Kruchinina ,Mikhail Voevoda ,Sergey Peltek . 分析科学方法和仪器期刊（英文） . 2013,第2期
• 2. Hepatic portal venous gas: Physiopathology, etiology, prognosis and treatment [J] . Bassam Abboud ,Jad El Hachem ,Thierry Yazbeck . 世界胃肠病学杂志：英文版 . 2009,第29期
• 3. Augev Method and an Innovative Use of Vocal Spectroscopy in Evaluating and Monitoring the Rehabilitation Path of Subjects Showing Severe Communication Pathologies [J] . Antonia Campanella ,Fabio Manca ,Claudia Marin . 临床医学国际期刊（英文） . 2019,第2期
• 4. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 5. Histopathology of renal asphyxia in newborn piglets: Individual susceptibility to tubular changes [J] . Clara Gerosa ,Nicoletta Iacovidou ,Ioanna Argyri . 世界肾病学杂志：英文版 . 2015,第2期
• 6. 网状纤维和Masson三色套染法在肝脏病理诊断中的应用体会 [C] . 张红雷 ,王跃 ,王泰龄 . 中华医学会病理学分会2011年全国病理技术新进展研讨会 . 2011
• 7. 骨桥蛋白在日本血吸虫感染小鼠肝脏中的表达及其中和抗体对肝脏病理改变的影响 [A] . 陈柏林 . 2012