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Structure based alignment and clustering of proteins (STRALCP)
Structure based alignment and clustering of proteins (STRALCP)
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机译：基于结构的蛋白质比对和聚类（STRALCP）
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摘要
Disclosed are computational methods of clustering a set of protein structures based on local and pair-wise global similarity values. Pair-wise local and global similarity values are generated based on pair-wise structural alignments for each protein in the set of protein structures. Initially, the protein structures are clustered based on pair-wise local similarity values. The protein structures are then clustered based on pair-wise global similarity values. For each given cluster both a representative structure and spans of conserved residues are identified. The representative protein structure is used to assign newly-solved protein structures to a group. The spans are used to characterize conservation and assign a “structural footprint” to the cluster.
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