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CHEMICALLY-DEFINED ARRAYS FOR SCREENING CELL-SUBSTRATE INTERACTIONS

机译:化学定义的数组,用于筛选细胞-基质相互作用

摘要

Patterned SAM arrays and methods of preparing patterned SAM arrays are disclosed. Advantageously, the methods used to prepare the patterned SAM arrays allow for controlling SAM spot-to-spot conditions such as ligand identity and ligand density, which allows for preparing a wide range of SAM spots in a single array format. Additionally, the patterned SAM arrays of the present disclosure support the culture of a range of cell types. The patterned SAM arrays offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation.
机译:公开了图案化的SAM阵列和制备图案化的SAM阵列的方法。有利地,用于制备图案化SAM阵列的方法允许控制SAM点对点条件,例如配体同一性和配体密度,这允许以单阵列形式制备各种SAM点。另外,本公开的图案化的SAM阵列支持多种细胞类型的培养。图案化的SAM阵列提供了快速筛选底物成分以影响细胞附着,扩散,增殖,迁移和分化的能力。

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