首页> 外国专利> SPLICE VARIANT SPECIFIC MESSENGER RNA TRANSCRIPTS AS BIOMARKERS OF PARKINSON'S DISEASE

SPLICE VARIANT SPECIFIC MESSENGER RNA TRANSCRIPTS AS BIOMARKERS OF PARKINSON'S DISEASE

机译:多种多样的特定信使RNA转录作为帕金森氏病的生物标记

摘要

The present invention provides a method and a diagnostic kit for diagnosing the presence of Parkinson's disease in a human subject. The method includes the steps of: (1) extracting RNA molecules from a blood sample of the human subject to define a test sample; (2) measuring the amount of each RNA molecule having Sequence ID Nos. 1-14 in the test sample; (3) comparing the amount of each of the RNA molecules having Sequence ID Nos. 1-14 to the amount of RNA molecules having Sequence ID Nos. 1-14 present in a control sample to determine how many of the RNA molecules of Sequence ID Nos. 1-14 are present in a significant amount in the test sample greater or less than in the control sample to define a number of biomarkers; and (4) diagnosing the presence of Parkinson's disease in the human subject if the number of biomarkers is equal to or greater than five.
机译:本发明提供了一种用于诊断人类受试者中帕金森氏病的方法和诊断试剂盒。该方法包括以下步骤:(1)从人类受试者的血液样品中提取RNA分子以限定测试样品; (2)测量测试样品中具有序列ID号1-14的每个RNA分子的量; (3)比较序列ID号为1-14的每个RNA分子的量与对照样品中存在序列号为1-14的RNA分子的量,以确定多少个序列ID的RNA分子1-14号存在于测试样品中的数量要大于或小于对照样品,以定义许多生物标记物。 (4)如果生物标志物的数量等于或大于五个,则诊断人类受试者中存在帕金森氏病。

著录项

  • 公开/公告号US2013079235A1

    专利类型

  • 公开/公告日2013-03-28

    原文格式PDF

  • 申请/专利权人 JUDITH A. POTASHKIN;

    申请/专利号US201113240821

  • 发明设计人 JUDITH A. POTASHKIN;

    申请日2011-09-22

  • 分类号C40B30/04;C40B40/06;

  • 国家 US

  • 入库时间 2022-08-21 16:48:55

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