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CD4 T-CELLS INVOLVED IN MAMMALIAN HOST RESPONSE TO EPITHELIAL CELL INFECTIONS AND USES THEREOF

机译：哺乳动物宿主中涉及上皮细胞感染的CD4 T细胞及其用途

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摘要

MHC class II-restricted Chlamydia-specific CD4 T cell clones recognize infected upper reproductive tract epithelial cells as early as 12 hours post infection. The timing and degree of T cell activation are dependent on the interferon milieu. Different interferons have different effects on T-cell activation; interferon IFN-β blunts IFN-γ induced up regulation of epithelial cell surface MHC class II and T cell activation. A subset of CD4 T-cells that was especially good at clearing Chlamydia infections from the genital tracts of infected mice was found to express the genes Casd1 and Plac8. The mouse Casd1 genes shares some 95 percent identity with the human gene. The differential expression of either Plac8 or Casd1 in COD cells in response to an infection of epithelial tissue provides a ready methodology for the identification of individuals exposed to epithelial infections and a tool for developing vaccines against pathogens that infect epithelial tissue.

机译：MHC II类限制的衣原体特异性CD4 T细胞克隆最早在感染后12小时就识别出感染的上生殖道上皮细胞。 T细胞活化的时机和程度取决于干扰素的环境。不同的干扰素对T细胞活化的影响不同。干扰素IFN-β钝化IFN-γ诱导上皮细胞表面MHC II类和T细胞活化的上调。发现一个特别擅长从感染小鼠生殖道清除衣原体感染的CD4 T细胞亚群表达Casd1和Plac8基因。小鼠Casd1基因与人类基因具有约95％的同一性。响应上皮组织感染，COD细胞中Plac8或Casd1的差异表达为鉴定暴露于上皮感染的个体提供了现成的方法，并为开发针对感染上皮组织的病原体的疫苗提供了工具。 展开▼

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公开/公告号US2013047274A1

专利类型

公开/公告日2013-02-21

原文格式PDF

申请/专利权人 RAYMOND M. JOHNSON;
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申请/专利号US201113579136

发明设计人 RAYMOND M. JOHNSON;
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申请日2011-02-15

分类号G01N33/53;A01K67/027;C40B30/04;C12Q1/02;C12Q1/68;

国家 US

入库时间 2022-08-21 16:48:55

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