首页> 外国专利> TRANSITION METAL MEDIATED OXIDATION OF HETERO ATOMS IN ORGANIC MOLECULES COORDINATED TO TRANSITION METALS: OXIDATION OF COORDINATED BENZIMIDAZOLE TO OMEPRAZOLE

TRANSITION METAL MEDIATED OXIDATION OF HETERO ATOMS IN ORGANIC MOLECULES COORDINATED TO TRANSITION METALS: OXIDATION OF COORDINATED BENZIMIDAZOLE TO OMEPRAZOLE

机译:过渡金属介导的有机分子中杂原子间杂原子的氧化:协调的苯并咪唑为奥美唑的氧化

摘要

The present invention is directed to a process for the catalytic oxidation of the thioether 5-methoxy-2-((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)methylthio)-1H-benzimidazole to its sulfoxide: 5-methoxy-2-((4-methoxy-3,5-dimethyl-2-pyridinyl) methyl) methylsulfinyl)-1H-benzimidazole comprising: reacting the thioether with: 1) a transition metal catalyst; and, 2) an oxygen source; wherein the thioether is oxidized to the sulfoxide commonly known as omeprazole and wherein one of either the R and S enantiomers is formed to an enantiomeric excess.
机译:本发明涉及将硫醚5-甲氧基-2-(((4-甲氧基-3,5-二甲基-2-吡啶基)甲基)甲硫基)-1H-苯并咪唑催化氧化为亚砜的方法:5 -甲氧基-2-(((4-甲氧基-3,5-二甲基-2-吡啶基)甲基)亚甲基磺酰基)-1H-苯并咪唑,其包括:使硫醚与以下物质反应:1)过渡金属催化剂; 2)氧气源;其中硫醚被氧化成亚砜,通常称为奥美拉唑,并且其中R和S对映体之一形成对映体过量。

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