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Being production manner of the silica nano grain which adds the silane coupling medicine to the converse micellar distributed system which consists of with the silica nano grain, and the surface active agent in
Being production manner of the silica nano grain which adds the silane coupling medicine to the converse micellar distributed system which consists of with the silica nano grain, and the surface active agent in
PROBLEM TO BE SOLVED: To provide: a production method by which silica nanoparticles having a narrow particle size distribution and an average particle diameter of nanometer order (e.g., not larger than 300 nm) are inexpensively produced in a high yield; silica nanoparticles produced by the method; and a labeling reagent excellent in reproducibility of a measured result and enabling the high-sensitivity analysis of an infinitesimal amount of target sample to be performed.;SOLUTION: The method for producing silica nanoparticles comprises: adding a silane coupling agent to a reverse micelle dispersion system composed of a surfactant in a hydrophobic solvent, water containing a basic electrolyte and a polyol; and hydrolyzing and polymerizing the silane coupling agent with the water to form silica nano-particles.;COPYRIGHT: (C)2009,JPO&INPIT
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