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Identification and engineering modification of antibodies having mutant Fc region and methods of use thereof
Identification and engineering modification of antibodies having mutant Fc region and methods of use thereof
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机译：具有突变Fc区的抗体的鉴定和工程修饰及其使用方法
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摘要
The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds Fc³RIIIA and/or Fc³RIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by Fc³R is desired, e.g. , cancer, infections disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.
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