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Methods for treating alcohol addiction, alcohol use disorders and alcohol abuse, including administration of dihydromyricetin

机译:治疗酒精成瘾,酒精使用障碍和酒精滥用的方法,包括给予双氢杨梅素

摘要

Disclosed herein are methods for treating alcohol intoxication, alcohol use disorders and alcohol abuse which comprise the administration of dihydromyricetin. As disclosed herein, dihydromyricetin potentiates the activity of GABAARs having the alpha4-beta-delta subunit which is associated with the effects of ethanol, antagonizes the actions of ethanol on the GABAARs, acts on the benzodiazepine sites of GABAARs, and inhibits, reduces and/or reverses some or all of the GABAAR plasticity which is caused by exposure to ethanol.
机译:本文公开了用于治疗酒精中毒,酒精使用障碍和酒精滥用的方法,其包括给予二氢杨梅素。如本文所公开的,二氢杨梅素增强了具有α4-β-δ亚基的GABAAR的活性,该α4-β-δ亚基与乙醇的作用有关,拮抗乙醇对GABAAR的作用,作用于GABAAR的苯并二氮杂位,并抑制,降低和/或逆转了由于暴露于乙醇引起的部分或全部GABAAR可塑性。

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