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METHOD FOR PREDICTION OF DEVELOPING OCCUPATIONAL MALIGNANT SKIN GROWTHS IN FIBREGLASS PRODUCTION WORKERS

机译:预测玻璃纤维生产工人职业恶性皮肤生长的方法

摘要

FIELD: medicine.;SUBSTANCE: DNA is recovered from peripheral venous blood for the purpose of analysing dup 16 polymorphism of a 3rd intervening sequence and Arg72Pro polymorphism of a 4th exon of the TP53 gene. If observing the combinations of the *Arg/*Pro and *W/*dup 16 genotypes, a risk of developing malignant skin growths is predicted. The *Arg/*Arg and *W/*W genotypes enables to predict resistance to the onset of the disease.;EFFECT: creation of the prognostic criteria of developing malignant skin growths or stability thereto in fibreglass production workers as shown by molecular-genetic markers.;3 tbl, 2 ex
机译:领域:医学;;物质:从外周静脉血中回收DNA,用于分析3 rd 插入序列的dup 16多态性和4 外显子的Arg72Pro多态性TP53基因。如果观察到* Arg / * Pro和* W / * dup 16基因型的组合,则有发生恶性皮肤生长的风险。 * Arg / * Arg和* W / * W基因型能够预测对疾病发作的抵抗力;效果:建立玻璃纤维生产工人恶性皮肤生长或皮肤恶性生长的预后标准,如分子遗传学所示标记; 3 tbl,2 ex

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