首页> 外国专利> SUBTYPE H1N1 INFLUENZA VIRUS STRAIN A/RUSSIA/OL/2009-MA FOR STUDY OF THERAPEUTIC AND PREVENTIVE ACTIVITY OF ANTIVIRAL PREPARATIONS in vitro AND in vivo

SUBTYPE H1N1 INFLUENZA VIRUS STRAIN A/RUSSIA/OL/2009-MA FOR STUDY OF THERAPEUTIC AND PREVENTIVE ACTIVITY OF ANTIVIRAL PREPARATIONS in vitro AND in vivo

机译：H1N1流感病毒亚型A / RUSSIA / OL / 2009-MA，用于体外和体内抗病毒制剂的治疗和预防活性

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FIELD: medicine.;SUBSTANCE: subtype H1N1 influenza virus strain A/Russia/Ol/2009-ma is intended for study of the efficacy of therapeutic and preventive preparations for influenza virus in experiments in vitro and in vivo. The strain is deposited in the Collection of Cultures of the State Research Centre for Virology and Biotechnology "Vector" No.V-511. The strain is applied in determining definition influenza activity of the preparations in vitro with using MDCK cells. The strain provides a basis to create an adequate model for studying of activity of antiviral preparations for subtype H1N1 influenza virus in vivo consisting in intranasal infection of Balb/c mice of weight 14-16 g with the given strain.;EFFECT: strain is adapted for mice and is able to cause a lethal infection in mice that simplifies estimating the efficacy of influenza preparations.;3 dwg, 4 tbl, 3 ex

机译：领域：医学;物质：H1N1亚型流感病毒株A / Russia / Ol / 2009-ma用于研究流感病毒的治疗和预防制剂在体内和体外实验中的功效。该菌株保藏在国家病毒学和生物技术研究中心的文化收藏中，“载体” V-511。该菌株用于通过使用MDCK细胞在体外确定制剂的定义流感活性。该菌株为建立合适的模型提供基础，用于研究H1N1亚型流感病毒在体内的抗病毒制剂的活性，该模型包括用给定菌株经鼻内感染重达14-16 g的Balb / c小鼠。用于小鼠，并能够在小鼠中引起致命的感染，从而简化了流感制剂的疗效评估。; 3 dwg，4 tbl，3 ex

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公开/公告号RU2451072C1

专利类型
公开/公告日2012-05-20

原文格式PDF
申请/专利权人 FEDERALNOE BJUDZHETNOE UCHREZHDENIE NAUKI GOSUDARSTVENNYJ NAUCHNYJ TSENTR VIRUSOLOGII I BIOTEKHNOLOGII VEKTOR (FBUN GNTS VB VEKTOR);
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申请/专利号RU20100142478
发明设计人 ROMANOVSKAJA ALESJA ALEKSANDROVNA;SHARSHOV KIRILL ALEKSANDROVICH;ZAJKOVSKAJA ANNA VLADIMIROVNA;DURYMANOV ALEKSANDR GAVRILOVICH;SHESTOPALOV ALEKSANDR MIKHAJLOVICH;
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申请日2010-10-18
分类号C12N7;A61K39/145;
国家 RU
入库时间 2022-08-21 17:06:03

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