首页> 外国专利> METHOD FOR HYPOESTROGEN-INDUCED ENDOTHELIAL DYSFUNCTION CORRECTION WITH LOZARTAN IN COMPLEX WITH MIXED SOLUTIONS OF HOMOEOPATHIC DILUTIONS OF POLYCLONAL RABBIT C12, C30, C200 ANTIBODIES TO HUMAN ENDOTHELIAL NITROGEN OXIDE SYNTHASE

METHOD FOR HYPOESTROGEN-INDUCED ENDOTHELIAL DYSFUNCTION CORRECTION WITH LOZARTAN IN COMPLEX WITH MIXED SOLUTIONS OF HOMOEOPATHIC DILUTIONS OF POLYCLONAL RABBIT C12, C30, C200 ANTIBODIES TO HUMAN ENDOTHELIAL NITROGEN OXIDE SYNTHASE

机译：洛沙坦与多克隆兔C12，C30，C200抗体对人血管内皮一氧化氮合酶的同质稀释混合溶液复杂的低氧诱导内皮功能失调的方法

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FIELD: medicine.;SUBSTANCE: hypoestrogen-induced endothelial dysfunction correction in white female Wistar rats, hypoestrogen-induced endothelial dysfunction is simulated by bilateral ovariectomy. The dysfunction correction is ensured by daily intragastric introduction of lozartan 6 mg/kg and daily introduction of mixed solutions of homoeopathic dilutions of polyclonal rabbit C12, C30, C200 antibodies to human endothelial nitrogen oxide synthase once a day added to drinking bowls.;EFFECT: method provides effective correction with reducing an endothelial dysfunction coefficient in females to the level observed in intact animals ensured by the effect on various developmental mechanisms of this dysfunction in hypoestrogenic conditions.;1 ex, 2 tbl

机译：领域：医学;研究对象：雌性雌性Wistar大鼠的雌激素诱导的内皮功能障碍矫正，通过双侧卵巢切除术模拟雌激素诱导的内皮功能障碍。每天向胃杯中加入洛沙坦6 mg / kg的胃内引入和每天向人碗中引入抗人内皮型一氧化氮合酶多克隆兔C12，C30，C200抗体的同种异体稀释混合溶液的方法可确保功能障碍的矫正;效果：该方法可通过降低雌性动物的内皮功能障碍系数至完整动物中观察到的水平来提供有效的矫正，该作用水平在雌激素低下的情况下通过对该功能障碍的各种发育机制的影响得以保证。; 1 ex，2 tbl

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公开/公告号RU2437162C1

专利类型
公开/公告日2011-12-20

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申请/专利权人 GOSUDARSTVENNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO PROFESSIONALNOGO OBRAZOVANIJA KURSKIJ GOSUDARSTVENNYJ MEDITSINSKIJ UNIVERSITET FEDERALNOGO AGENTSTVA PO ZDRAVOOKHRANENIJU I SOTSIALNOMU RAZVITIJU;
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申请/专利号RU20100116599
发明设计人 POKROVSKIJ MIKHAIL VLADIMIROVICH;POKROVSKAJA TATJANA GRIGOREVNA;BELOUS ALEKSANDR SERGEEVICH;ARTJUSHKOVA ELENA BORISOVNA;BELOUS VIKTOR SERGEEVICH;GUDYREV OLEG SERGEEVICH;KOROKIN MIKHAIL VIKTOROVICH;CHERNOMORTSEVA ELENA STANISLAVOVNA;STABROVSKAJA NADEZHDA VLADIMIROVNA;GUREEV VLADIMIR VLADIMIROVICH;KLJAVS JURIJ PETROVICH;TEREKHOVA ELENA GENNADEVNA;KOLESNIK INGA MIKHAJLOVNA;JAKUSHEV VLADIMIR IVANOVICH;DOLZHENKOVA TATJANA VLADIMIROVNA;KOROKINA LILIJA VIKTOROVNA;BABKO ANNA VLADIMIROVNA;
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申请日2010-04-26
分类号G09B23/28;A61K31/4184;A61K39/395;A61P9/02;
国家 RU
入库时间 2022-08-21 17:06:22

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