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Treadmill for physical health evaluation of experimental mice

机译:跑步机,用于评估实验小鼠的身体健康

摘要

The utility model solves the issues in the field of pharmaceutical research, related to the search of chemical compounds possessing aktoprotektornyh action. Treadmill 1 comprises a box of rectangular shape without a bottom, which is mounted on a standard sports treadmill and 9 rigidly fixed in 4 points at the edges of the treadmill frame. Inside the box 1 is divided by partitions into six compartments 2 3 representing individual racetracks for mice, each of which is provided with a removable cover (not shown conditionally in the drawing), allowing the mouse placed on the track and remove it therefrom when necessary. The rear frame 1 is mounted an electric field 4, a metal plate connected to the current source 8. All parts of the box - a housing walls, removable lid are made of transparent material such as plexiglass. A mouse is placed in the compartment 3 include sports treadmill and force it to run in the compartment. When physical fatigue the mouse moves to the electric floor and gets irritated weak electric current that causes it to return to the track and continue to run the treadmill. By running test in mice treadmill using special methods, determine their physical working capacity, Fig.1 test data are used to assess the performance of the experimental mice with the purpose of identification and selection of chemical compounds having actoprotective activity that is necessary for search, creation and implementation of highly effective funds, antidotes, biologically active additives (BAA) for health and safety in non-disadvantaged areas, disaster medicine, military and sports Medicine for the Russian Olympic Committee.
机译:本实用新型解决了药物研究领域中与具有aktoprotektornyh作用的化合物的寻找有关的问题。跑步机1包括一个无底的矩形盒子,该盒子安装在标准运动跑步机上,并且9刚性固定在跑步机框架边缘的4个点上。盒子1的内部被隔板分成六个隔间2 3,分别代表小鼠的赛道,每个隔间都配有可移动的盖子(图中未有条件显示),允许鼠标放在轨道上,并在必要时将其从轨道上移出。 。后框架1安装有电场4,连接到电流源8的金属板。盒子的所有部分-外壳壁,可移动的盖子均由有机玻璃等透明材料制成。将鼠标放置在包括运动跑步机的隔室3中,并迫使其在隔室中运行。当身体疲劳时,鼠标移至电地板并受到刺激的微弱电流,导致其返回轨道并继续运行跑步机。通过使用特殊方法在小鼠跑步机上进行测试,确定其物理工作能力,图1测试数据用于评估实验小鼠的性能,目的是识别和选择具有保护作用的化合物,这些化合物对于搜寻具有必要的保护作用,为俄罗斯奥委会创建和实施高效的资金,解毒剂,生物活性添加剂(BAA),以促进非弱势地区的健康与安全,灾难医学,军事和体育医学。

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