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Copper ion detection via direct displacement using dimeric zinc complexes and preparing method thereof
Copper ion detection via direct displacement using dimeric zinc complexes and preparing method thereof
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机译：二聚锌配合物直接置换检测铜离子及其制备方法
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摘要
The present invention relates to an amino acid Schiff base zinc dinuclear compound that selectively detects copper ions in an aqueous solution, and more particularly, to an amino acid Schiff base zinc dinuclear compound that selectively detects biologically important copper ions in an aqueous solution. It provides a method of synthesis in a single step process. The present invention is based on the lysine ligand in the synthesis of a dinuclear zinc compound having a lysine Schiff base ligand [Zn 2 ( r , s -lysH) 2 (μ-OAc) 2 ] (Compound 1), [Zn 2 ( s -lysH) 2 (NO 3 ) 2 ] (Compound 2) and [H 2 lys = 6-amino-2-{(2-hydroxybenzylidene) amino} hexanoic acid] were synthesized by an in situ method. This dinuclear zinc compound was synthesized in a single step process using L or D / L-lysine Schiff base ligands, which were analyzed by various spectroscopic techniques and by single crystal X-ray diffraction methods. Compounds 1 and 2 of the present invention have fluorescence properties and good solubility in aqueous solution, so that the physiologically important copper ions can be used as a central metal direct substitution method using fluorescent and colorimetric properties at a physiologically stable pH. Detect. These compounds were found to have a twisted square pyramidal bond structure with a central metal ion. Also, for the analysis of the binding mechanism of the compound, compound 2 was directly synthesized using copper ions, and compound 3 was synthesized similar to that of compound 2, and only the central metal was converted to copper. This made it clear that the bonding ratio between compound 2 and copper ions was 1: 2.
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机译：氨基酸席夫碱锌双核化合物技术领域本发明涉及一种选择性地检测水溶液中铜离子的氨基酸席夫碱锌双核化合物，更具体地，涉及一种选择性检测水溶液中生物学上重要的铜离子的氨基酸席夫碱锌双核化合物。它提供了一步合成的方法。本发明基于赖氨酸配体的合成，所述双核锌化合物具有赖氨酸席夫碱配体[Zn 2 （ r ， s -lysH） 2 （μ-OAc） 2 ]（化合物1），[Zn 2 （ s -lysH） 2 （否 3 ） 2 ]（化合物2）和[H 2 lys = 6-通过原位方法合成了氨基-2-{（2-羟基亚苄基）氨基}己酸]。使用L或D / L-赖氨酸Schiff碱配体通过一步法合成该双核锌化合物，并通过各种光谱技术和X射线单晶衍射法对其进行了分析。本发明的化合物1和2具有荧光性质，并且在水溶液中具有良好的溶解性，因此，在生理上稳定的pH下，利用荧光和比色性质，可以将生理上重要的铜离子用作中心金属直接取代方法。检测。发现这些化合物具有带有中心金属离子的扭曲的方形锥体键结构。另外，为了分析化合物的结合机理，使用铜离子直接合成化合物2，并且类似于化合物2的合成化合物3，仅中心金属转化为铜。这清楚地表明化合物2与铜离子之间的键合比为1：2。
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