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Osteonecrosis of jaw inhibitor comprising amine-derivatives, and pharmaceutical composition for osteonecrosis of jaw preventing or treating comprising thereof
Osteonecrosis of jaw inhibitor comprising amine-derivatives, and pharmaceutical composition for osteonecrosis of jaw preventing or treating comprising thereof
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机译：包含胺衍生物的颌骨抑制剂的骨坏死以及用于预防或治疗其的颌骨坏死的药物组合物
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摘要
The present invention is a pharmaceutical for prevention or treatment of side effects bisphosphonate formulation comprising as an active ingredient, the amine derivative relates to a composition. Derivative compositions of the present invention control the expression of HIF-1 as a chaperone protein and low use amount, the HIF-1 is to control the expression of the BCL-xL protein to suppress cell death. This can prevent and treat the side effects caused by the necrosis of the jaw of bisphosphonates osteoporosis agents that induce apoptosis of the conventionally used bone-related cells, osteoblasts or osteoclasts. Thus, the use of bisphosphonates in osteoporosis treatment agents commonly used include, without applying the constraints, there is an advantage in that only the side effects can be reduced with use of the compositions of the present invention. ; 展开▼
