首页> 外国专利> BIOMARKERS, KITS COMPRISING SINGLE NUCLEOTIDE POLYMORPHISM AND DIAGNOSING METHODS FOR CHILDHOOD LEUKEMIA USING THE SAME

BIOMARKERS, KITS COMPRISING SINGLE NUCLEOTIDE POLYMORPHISM AND DIAGNOSING METHODS FOR CHILDHOOD LEUKEMIA USING THE SAME

机译:生物标记物,包含单个核苷酸多态性的试剂盒以及使用该方法诊断儿童白血病的方法

摘要

PURPOSE: A biomarker for leukemia in children and a method for predicting the risk of leukemia in children are provided to check the genetic character of an individual and to diagnose risk. CONSTITUTION: A marker for diagnosing leukemia in children contains: a polynucleotide containing 8-200 serial base sequences with an SNP of rs703817, rs17433222, or rs3794845; or a complement thereof. A kit for diagnosing leukemia in children contains the marker. A method for diagnosing leukemia in children comprises: a step of preparing nucleic acid samples from a test sample; a step of determining the base sequence of an SNP of rs703817, rs17433222, or rs3794845 in the nucleic acid sample; and a step of determining the risk of leukemia in case that rs703817, rs17433222, and rs3794845 is GG, GG, and CC, respectively.
机译:目的:提供儿童白血病的生物标志物和预测儿童白血病风险的方法,以检查个人的遗传特征并诊断风险。构成:用于诊断儿童白血病的标记物包括:多核苷酸,其含有8-200个序列碱基序列,其SNP为rs703817,rs17433222或rs3794845;或其补充。用于诊断儿童白血病的试剂盒包含标记。一种儿童白血病的诊断方法,包括:从测试样品中制备核酸样品的步骤;确定核酸样品中rs703817,rs17433222或rs3794845的SNP的碱基序列的步骤;以及在rs703817,rs17433222和rs3794845分别为GG,GG和CC的情况下确定白血病风险的步骤。

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