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METHOD OF DISEASE-INDUCED AND RECEPTOR-MEDIATED STEM CELL NEUROPROTECTION

机译:疾病诱导和受体介导的干细胞神经保护方法

摘要

Stem cells are exposed to disease condition (the OGD stroke model), that mimics the target disease (stroke), allowing the stem cells to exert better neuroprotective effects. Thus, the present technology demonstrates a disease-tailored stem cell therapy. The present invention discloses that the administration of a therapeutically effective amount of amnion derived stem cells concomitantly with a therapeutically effective dose of melatonin provides additive/synergistic neuroprotective effects. Moreover, the present invention offers an equally robust technology employing a receptor-regulated mechanism, whereby stem cells can be enhanced (melatonin treatment) over their basal level (lack of melatonin treatment), facilitating a regulation of stem cells.
机译:干细胞暴露于模拟目标疾病(中风)的疾病状态(OGD中风模型),从而使干细胞发挥更好的神经保护作用。因此,本技术证明了针对疾病的干细胞疗法。本发明公开了治疗有效量的羊膜来源的干细胞与治疗有效量的褪黑激素的同时给药提供了加和/协同神经保护作用。此外,本发明提供了一种利用受体调节机制的同样强大的技术,由此可以在其基础水平上增强(褪黑激素处理)干细胞(褪黑激素处理),从而促进干细胞的调节。

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