首页> 外国专利> Hypoallergenic chimeric proteins belonging to the lipid transfer family of parietaria judaica for use in the treatment of allergies.

Hypoallergenic chimeric proteins belonging to the lipid transfer family of parietaria judaica for use in the treatment of allergies.

机译:属于犹太教鞭毛虫脂质转移家族的低变应性嵌合蛋白,用于治疗过敏。

摘要

Hypoallergenic chimeric proteins belonging to the lipid transfer family of Parietaria judaica for use in the treatment of allergies.;The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics are described. Methods for producing these recombinant polypeptides in heterologous expression systems are also described. Efficient methods of purifying the chimeric proteins are also described.
机译:用于治疗过敏的属于 Parietaria judaica 的脂质转移家族的低变应原性嵌合蛋白。用于预防和治疗过敏,特别是花粉过敏。具体地,描述了由具有低变应原性特征的变应原Par j 1和Par j 2的片段组成的嵌合多肽。还描述了在异源表达系统中产生这些重组多肽的方法。还描述了纯化嵌合蛋白的有效方法。

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