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SCREENING METHOD FOR THE IDENTIFICATION OF TNF-PATHWAY MODULATORS USING TRADD/ REPORTER FUSION PROTEIN.
SCREENING METHOD FOR THE IDENTIFICATION OF TNF-PATHWAY MODULATORS USING TRADD/ REPORTER FUSION PROTEIN.
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机译:使用贸易/报告融合蛋白鉴定TNF途径调节剂的筛选方法。
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摘要
The present invention relates inter alia to methods for identifying modulators of tumour necrosis factor (TNF) signalling. In one aspect, the method involves identifying an agent that modulates a signalling pathway mediated by TNF, comprising the steps of providing a host cell comprising TNF receptor 1 (TNFR1)-associated death domain (TRADD) linked to a reporter molecule, and determining at least one cellular characteristic detectable by the reporter molecule in the host cell in the presence of TNF and in the presence and absence of a candidate modulator. The invention is suitable for high-throughput screening (HTS) and high-content screening (HCS), or a combination of HTS and HCS.
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