首页> 外国专利> A DERMACEUTICAL CREAM MADE USING SODIUM FUSIDATE, AND FLUTICASONE PROPIONATE, A PROCESS TO MAKE THE SAME AND A METHOD OF TREATMENT USING IT

A DERMACEUTICAL CREAM MADE USING SODIUM FUSIDATE, AND FLUTICASONE PROPIONATE, A PROCESS TO MAKE THE SAME AND A METHOD OF TREATMENT USING IT

机译：使用夫西地酸钠和丙酸氟替卡松制成的皮肤病药膏，制取相同药物的过程及其治疗方法

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摘要

The invention discloses a dermaceutical cream containing Fluticasone Propionate as a corticosteroid, and an antibacterial agent in the form of Fusidic acid, which Fusidic acid is formed in situ from Sodium Fusidate as the starting raw material, wherein Sodium Fusidate is converted into Fusidic acid under oxygen-free environment. The cream of the present invention has greater shelf-life stability and the finer particle size of the API than the conventional creams containing Fusidic acid. The cream of the present invention has greater shelf-life stability and the finer particle size of the API than the conventional creams containing Fusidic acid. The cream of the present invention contains Fusidic acid as the API that has been formed in situ from Sodium Fusidate, and Fluticasone Propionate, in a cream base comprising a preservative, an acid, a co-solvent, emulsifiers and a waxy material along with water, preferably purified water.

机译：本发明公开了一种以丙酸氟替卡松为皮质类固醇和夫西地酸形式的抗菌剂的皮肤护理霜，其以夫西地酸钠为原料原位形成夫西地酸，其中夫西地酸钠在氧气下转化为夫西地酸。无环境。与常规的含有夫西地酸的乳膏相比，本发明的乳膏具有更大的货架期稳定性和API的更细粒度。与常规的含有夫西地酸的乳膏相比，本发明的乳膏具有更大的货架期稳定性和API的更细粒度。本发明的乳膏在包含防腐剂，酸，助溶剂，乳化剂和蜡质材料以及水的乳膏基质中包含夫西地酸作为API，其由夫西地酸钠和氟替卡松丙酸酯原位形成。，最好是纯净水。

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公开/公告号WO2012035378A1

专利类型
公开/公告日2012-03-22

原文格式PDF
申请/专利权人 VANANGAMUDI SULUR SUBRAMANIAM;SRINIVASAN MADHAVAN;CHULLIEL NEELAKANDAN NARAYANAN;GHOSH KAUSIK;
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申请/专利号WO2010IB56124
发明设计人 VANANGAMUDI SULUR SUBRAMANIAM;SRINIVASAN MADHAVAN;CHULLIEL NEELAKANDAN NARAYANAN;GHOSH KAUSIK;
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申请日2010-12-30
分类号A61K9;A61K9/107;A61K31;A61K47/10;
国家 WO
入库时间 2022-08-21 17:17:09

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