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METHOD FOR THE SPATIALLY RESOLVED DETERMINATION OF PHYSICAL, CHEMICAL AND BIOLOGICAL PROPERTIES OR STATE VARIABLES

机译:空间分辨测定物理,化学和生物学性质或状态变量的方法

摘要

Method for the spatially resolved determination of physical, chemical and/or biological properties or state variables and/or the change therein in an examination area of an examination object by determining the change in the spatial distribution and/or the mobility, particularly the mobility in rotation, of magnetic particles in this examination area or in parts thereof as a function of the effect of physical, chemical and/or biological influencing variables on at least a part-area and/or in the physical, chemical and/or biological conditions in at least a part-area of the examination area, by means of the following steps: a) introducing covered and/or coated magnetic particles with at least one solid, viscous and/or liquid shell or coating into at least part of the examination area and/or introducing magnetic particles into at least part of the examination area and/or covering and/or coating at least some of these particles in the examination area, b) generating a magnetic field with a spatial profile of the magnetic field strength such that there is produced in the examination area a first part-area having a low magnetic field strength and a second part-area having a higher magnetic field strength, 15 c) changing the, in particular relative, spatial position of the two part-areas in the examination area or changing the magnetic field strength in the first part-area so that the magnetization of the particles is locally changed, d) detecting signals that depend on the magnetization in the examination area that is influenced by this change, and e) evaluating the signals so as to obtain information about the change in the spatial distribution and/or mobility of the magnetic particles in the examination area. The invention also relates to functionalized magnetic particle compositions and magnetic particle compositions suitable for use in the above method. The invention further also relates to an apparatus for the measurement of state variables in the examination area.
机译:通过确定空间分布和/或迁移率的变化,特别是在空间中的迁移率的变化,在空间上解析检查对象的检查区域中的物理,化学和/或生物学特性或状态变量和/或其中的变化的方法该检查区域或其部分中磁性粒子的旋转取决于物理,化学和/或生物学影响变量对至少一部分区域和/或物理,化学和/或生物学条件的影响。通过以下步骤,至少检查区域的一部分区域:a)将具有至少一种固体,粘性和/或液体壳或涂层的被覆盖和/或涂覆的磁性颗粒引入检查区域的至少一部分中和/或将磁性粒子引入检查区域的至少一部分和/或在检查区域中覆盖和/或覆盖这些粒子中的至少一些,b)产生磁场磁场强度的空间分布,以便在检查区域中产生具有低磁场强度的第一部分区域和具有较高磁场强度的第二部分区域,15 c)改变了特别是相对的,检查区域中两个分区的空间位置或改变第一分区中的磁场强度,以便局部改变粒子的磁化强度,d)检测取决于检查区域中磁化强度的信号受该变化影响,并且e)评估信号,以获得关于检查区域中的磁性粒子的空间分布和/或迁移率的变化的信息。本发明还涉及官能化的磁性颗粒组合物和适用于上述方法的磁性颗粒组合物。本发明还涉及一种用于测量检查区域中的状态变量的设备。

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