首页> 外国专利> METHOD FOR SCREENING, USING GABA RECEPTORS, FOR PREPARATIONS FOR PREVENTING FETAL NEURAL DISEASE CAUSED BY ALCOHOL EXPOSURE DURING PREGNANCY

METHOD FOR SCREENING, USING GABA RECEPTORS, FOR PREPARATIONS FOR PREVENTING FETAL NEURAL DISEASE CAUSED BY ALCOHOL EXPOSURE DURING PREGNANCY

机译：使用GABA受体进行筛查的方法，用于预防妊娠期酒精暴露引起的胎儿神经疾病

页面导航

摘要
著录项
相似文献

摘要

The present invention relates to a method for screening for preparations for preventing fetal neural disease caused by alcohol exposure during pregnancy, comprising: a step of treating a fetus-derived specimen with ethanol to inhibit the expression of GABA_B1 receptors; and a step of treating the specimen with a candidate material, and checking the increase in the expression of one or more selected from a group consisting of GABA_B1 receptors, p-CREB and PKA. The present invention also relates to a method for predicting the probability of the onset of fetal neural disease caused by alcohol exposure during pregnancy, comprising measuring the decrease in the expression of GABA_B1 receptors in the fetus-derived specimen exposed to alcohol. The present invention also relates to a method for preparing compositions for preventing fetal neural disease caused by alcohol exposure during pregnancy, comprising: a step of treating a fetus-derived specimen exposed to alcohol with a candidate material, and checking the increase in the expression of one or more selected from a group consisting of GABA_B1 receptors, p-CREB and PKA; and a step of adding the candidate material that exhibits said increase in expression.

机译：本发明涉及一种用于预防由怀孕期间暴露于酒精引起的胎儿神经疾病的制剂的筛选方法，包括：用乙醇处理胎儿来源的标本以抑制GABA _{B1 表达的步骤。受体以及用候选材料处理标本，并检查选自GABA _{B1 受体，p-CREB和PKA的一种或多种表达的增加。本发明还涉及一种预测由怀孕期间酒精暴露引起的胎儿神经疾病发作的可能性的方法，包括测量胎儿来源的标本中GABA _{B1 受体表达的减少。接触酒精。本发明还涉及制备用于预防由怀孕期间酒精暴露引起的胎儿神经疾病的组合物的方法，该方法包括：用候选物质处理暴露于酒精的胎儿衍生样品的步骤，并检查其表达的增加。一个或多个选自GABA _{B1 受体，p-CREB和PKA;以及添加表现出所述表达增加的候选材料的步骤。}}}}

著录项

公开/公告号WO2011145905A3

专利类型
公开/公告日2012-05-03

原文格式PDF
申请/专利权人 INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY;KIM MYEONG OK;PARK MOON SEOK;PARK TAE JU;YANG BYOUNG CHUL;
展开▼

申请/专利号WO2011KR03725
发明设计人 KIM MYEONG OK;PARK MOON SEOK;PARK TAE JU;YANG BYOUNG CHUL;
展开▼

申请日2011-05-19
分类号G01N33/68;G01N33/15;
国家 WO
入库时间 2022-08-21 17:18:51

相似文献

专利
外文文献
中文文献