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USE OF RISPERIDONE N-OXIDE AS A PRODRUG IN ORAL, PARENTERAL, RECTAL OR TRANSDERMAL TREATMENT WITH RISPERIDONE
USE OF RISPERIDONE N-OXIDE AS A PRODRUG IN ORAL, PARENTERAL, RECTAL OR TRANSDERMAL TREATMENT WITH RISPERIDONE
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机译：使用利培酮一氧化氮作为前药在利培酮的口腔，腹腔，直肠或经皮治疗中
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摘要
The invention relates to the use of risperidone N-oxide as a prodrug in antipsychotic treatment. The use of N-oxide type as a prodrug generates a slow conversion to the active entity, risperidone, simultaneously with an increased time of in-vivo remanence, with constant exposure at the central level and reduction of inter-individual variability generated by the genetic polymorphism of the metabolizing enzyme.
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