首页> 外国专利> A process for Nymphayol17-(hexan-2yl)-10,13-dimethylhexadecahydro-1H-cyclopentaaphenanthren-3-ol from Nymphaea stellata with antidiabetic property

A process for Nymphayol17-(hexan-2yl)-10,13-dimethylhexadecahydro-1H-cyclopentaaphenanthren-3-ol from Nymphaea stellata with antidiabetic property

机译：一种具有降糖作用的星夜蛾Nymphayol [17-（己基-2yl）-10,13-二甲基十六氢-1H-环戊基[a]菲蒽-3-醇]的制备方法

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摘要

Nymphayol [17-(hexan-2-yl)-10, 13-dimethylhexadecahydro-lH-cyclopenta[a]phenanthren -3-ol], a novel crystal was isolated from chloroform extract of Nymphaea stellata Willd. Flower. It elicited significant hypoglycemic activity (60.33%) in Streptozotocin-diabetic rats and altered the pattern of glucose tolerance in diabetic rats. In addition, Nymphayol treatment increased plasma insulin levels significantly in streptozotocin-diabetic rats. The hypoglycemic effect of the Nymphayol was comparable with glibenclamide.

机译：Nymphayol [17-（hexa-2-yl）-10，13-methylhexadecahydro-1H-cyclopenta [a] phenanthren -3-ol]，从星状睡莲的氯仿提取物中分离出一种新型晶体。花。它在链脲佐菌素糖尿病大鼠中引起明显的降血糖活性（60.33％），并改变了糖尿病大鼠的葡萄糖耐量模式。此外，苯丙胺醇治疗可显着提高链脲佐菌素-糖尿病大鼠的血浆胰岛素水平。尼苯酚的降血糖作用与格列本脲相当。

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公开/公告号IN252169B

专利类型
公开/公告日2012-05-04

原文格式PDF
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申请/专利号IN1567/CHE/2007
发明设计人 SAVARIMUTHU IGNACIMUTHU;PANDURANGAN SUBASH-BABU;
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申请日2007-07-20
分类号A61K35/78;
国家 IN
入库时间 2022-08-21 17:23:54

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