首页> 外国专利> (54) Title: PARENTERAL FORMULATIONS OF GEMCITABINE DERIVATIVES (57) Abstract: The present invention relates to parenteral formulations for certain long chain saturated and monounsaturated fatty acid derivatives of 2',2'-difluorodeoxycytidine (Gemcitabine). In particular, the present invention relates to a parenteral pharmaceutical composition and a method of the preparation thereof in order to accommodate therapeutically effective doses of the said derivatives ameliorating compliance in the treatment of cancer. The composition has an average particle size in the range of 2.5-30 nm and typically contains a phospholipid. A preferred active ingredient is gemcitabine-5'-elaidic acid ester.

(54) Title: PARENTERAL FORMULATIONS OF GEMCITABINE DERIVATIVES (57) Abstract: The present invention relates to parenteral formulations for certain long chain saturated and monounsaturated fatty acid derivatives of 2',2'-difluorodeoxycytidine (Gemcitabine). In particular, the present invention relates to a parenteral pharmaceutical composition and a method of the preparation thereof in order to accommodate therapeutically effective doses of the said derivatives ameliorating compliance in the treatment of cancer. The composition has an average particle size in the range of 2.5-30 nm and typically contains a phospholipid. A preferred active ingredient is gemcitabine-5'-elaidic acid ester.

机译：（54）标题：吉西他滨衍生物的肠胃外制剂（57）摘要：本发明涉及2”，2”-二氟脱氧胞苷（吉西他滨）的某些长链饱和和单不饱和脂肪酸衍生物的肠胃外制剂。特别地，本发明涉及肠胃外药物组合物及其制备方法，以适应治疗有效剂量的所述衍生物，从而改善癌症治疗中的顺应性。该组合物的平均粒度为2.5-30nm，并且通常包含磷脂。优选的活性成分是吉西他滨-5”-花生酸酯。

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pThe present invention relates to parenteral formulations for certain long chain saturated and monounsaturated fatty acid derivatives of 2',2'-difluorodeoxycytidine (Gemcitabine). In particular, the present invention relates to a parenteral pharmaceutical composition and a method of the preparation thereof, in order to accommodate therapeutically effective doses of the said derivatives ameliorating compliance in the treatment of cancer. The composition has an average particle size in the range of 2.5-30 nm and typically contains a phospholipid. A preferred active ingredient is gemcitabine-5'-elaidic acid ester./p [WO2011062503A1]

机译：本发明涉及用于2'，2'-二氟脱氧胞苷（吉西他滨）的某些长链饱和和单不饱和脂肪酸衍生物的肠胃外制剂。特别地，本发明涉及肠胃外药物组合物及其制备方法，以适应治疗有效剂量的所述衍生物，从而改善癌症治疗中的顺应性。该组合物的平均粒度为2.5-30nm，并且通常包含磷脂。优选的活性成分是吉西他滨-5'-乌来酸酯。 [WO2011062503A1]

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公开/公告号IN2012MN01446A

专利类型
公开/公告日2012-08-24

原文格式PDF
申请/专利权人
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申请/专利号IN1446/MUMNP/2012
发明设计人 AHRABI SAYEH;MYHREN FINN;ERIKSEN OLE HENRIK;
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申请日2012-06-11
分类号A61K9/127;
国家 IN
入库时间 2022-08-21 17:23:58