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USE OF A PHARMACEUTICAL COMPOSITION COMPRISING AN OLIGONUCLEOTIDE IN THE PREPARATION OF MEDICAMENTS FOR TREATING B CELL NEOPLASM, AND EX VIVO METHODS OF INDUCING APOPTOSIS OF B-CELL NEOPLASTIC CELLS, COMPRISING CONTACTING SAID CELLS WITH SAID COMPOSITION
USE OF A PHARMACEUTICAL COMPOSITION COMPRISING AN OLIGONUCLEOTIDE IN THE PREPARATION OF MEDICAMENTS FOR TREATING B CELL NEOPLASM, AND EX VIVO METHODS OF INDUCING APOPTOSIS OF B-CELL NEOPLASTIC CELLS, COMPRISING CONTACTING SAID CELLS WITH SAID COMPOSITION
The invention provides nine oligonucleotides with sequences of SEQ ID NO: 1-9 or their functional homologues or a composition comprising the same and a method for treating B cell neoplasm by using the oligonucleotides or their functional homologues or the composition comprising the oligonucleotides. The oligonucleotides induce the apoptosis of B cell neoplastic cells, up-regulate CD40 on B cell neoplastic cells and stimulate the production of IL-10 from B cell neoplastic cells.
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机译：本发明提供了具有SEQ ID NO：1-9的序列或其功能同源物或包含该序列的组合物的九种寡核苷酸，以及通过使用该寡核苷酸或其功能同源物或包含该寡核苷酸的组合物治疗B细胞瘤的方法。寡核苷酸诱导B细胞瘤细胞的凋亡，上调B细胞瘤细胞上的CD40并刺激B细胞瘤细胞产生IL-10。
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