首页>
外国专利>
ISOLATED PROTEIN AND POLYNUCLEOTIDE, AN EXPRESSION VECTOR CONTAINING THE POLYNUCLEOTIDE AND AN ASSAY FOR DETERMINING THE PRESENCE OF PROSTATE OR COLON CANCER BY CONTACTING SAID ISOLATED PROTEIN WITH A PROSTATE OR COLON TISSUE
ISOLATED PROTEIN AND POLYNUCLEOTIDE, AN EXPRESSION VECTOR CONTAINING THE POLYNUCLEOTIDE AND AN ASSAY FOR DETERMINING THE PRESENCE OF PROSTATE OR COLON CANCER BY CONTACTING SAID ISOLATED PROTEIN WITH A PROSTATE OR COLON TISSUE
Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell surface serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provided are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labelled with a detectable marker or toxin or therapeutic composition. Several monoclonal antibodies specifically reactive with 20P1F12/TMPRSS2 are also described herein.
展开▼
