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USE OF 3-AMINO-1-PROPANESULFONIC ACID OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OR PREVENTION OF INFLAMMATION, NEURONAL CELL TOXICITY, NEURONAL CELL DEATH OR NEURONAL CELL LOSS IN A CONDITION OR DISEASE IN WHICH A-BETA AMYLOIDOGENIC PROTEINS OR PEPTIDES ARE PRESENT
USE OF 3-AMINO-1-PROPANESULFONIC ACID OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OR PREVENTION OF INFLAMMATION, NEURONAL CELL TOXICITY, NEURONAL CELL DEATH OR NEURONAL CELL LOSS IN A CONDITION OR DISEASE IN WHICH A-BETA AMYLOIDOGENIC PROTEINS OR PEPTIDES ARE PRESENT
Anionic compounds, including sulfonates, are capable of blocking Aβ-induced macrophage activation (or macrophage activation induced by other amyloidogenic proteins or peptides). Such compounds can inhibit the inflammatory process, e.g., in the brain of a subject suffering from a disease characterized by Aβ deposition, such as Alzheimer's disease.
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