首页> 外国专利> Method for treating HIV infection in an individual, Method for imaging to detect or diagnose HIV infection in an individual, composition

Method for treating HIV infection in an individual, Method for imaging to detect or diagnose HIV infection in an individual, composition

机译:治疗个体HIV感染的方法,成像以检测或诊断个体HIV感染的方法,组合物

摘要

METHOD FOR TREATING HIV INFECTION IN AN INDIVIDUAL, METHOD FOR LATENT IMAGE DETECTING OR DIAGNOSING HIV INFECTION IN AN INDIVIDUAL, COMPOSITION. The present invention relates to methods and compositions for treating HIV infection in an individual. The compositions can comprise a target molecule against an HIV antigen, such as an anti-HIV antibody or antibody fragment. The anti-HIV antibody or fragment can be conjugated to a variety of cytotoxic agents, such as doxorubrc ± n. In a preferred embodiment, the antibody or fragment is P4 / D10. Other modalities may concern methods of imaging, detecting or diagnosing HIV infection in an individual using an anti-HIV antibody or fragment conjugated to a diagnostic agent. In alternative embodiments, a bispecific antibody with at least one agglutination site for an HIV antigen and at least one agglutination site for a carrier molecule can be administered, optionally followed by a bleaching agent, followed by administration of a conjugated carrier molecule for a therapeutic agent.
机译:用于个体治疗HIV感染的方法,用于个体组成的隐匿图像检测或诊断HIV感染的方法。本发明涉及用于治疗个体HIV感染的方法和组合物。该组合物可以包含针对HIV抗原的靶分子,例如抗HIV抗体或抗体片段。可以将抗HIV抗体或片段与多种细胞毒性剂(例如doxorubrc±n)偶联。在一个优选的实施方案中,抗体或片段是P4 / D10。其他方式可能涉及使用抗HIV抗体或与诊断剂偶联的片段对个体进行HIV成像,检测或诊断的方法。在替代实施方案中,可以施用具有针对HIV抗原的至少一个凝集位点和针对载体分子的至少一个凝集位点的双特异性抗体,任选地随后给予漂白剂,随后给予针对治疗剂的缀合的载体分子。

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