• 主题
高级搜索  >
历史搜索 清空历史
首页> 外国专利> method for treating a glioma-like tumor, glioma prognosis and / or diagnosis methods, monitoring or diagnostic method, method for inhibiting the size or growth of a glioma-like tumor, methods for therapeutically treating, method for determining the level of expression of pn, prolif or mes glioma determinants ('gdm'), method for predicting survival time, method for diagnosing the severity of a glioma-like tumor and use

method for treating a glioma-like tumor, glioma prognosis and / or diagnosis methods, monitoring or diagnostic method, method for inhibiting the size or growth of a glioma-like tumor, methods for therapeutically treating, method for determining the level of expression of pn, prolif or mes glioma determinants ('gdm'), method for predicting survival time, method for diagnosing the severity of a glioma-like tumor and use

机译：用于治疗神经胶质瘤样肿瘤的方法，神经胶质瘤的预后和/或诊断方法，监测或诊断方法，用于抑制神经胶质瘤样肿瘤的大小或生长的方法，用于治疗的方法，用于确定pn表达水平的方法，prolif或mes神经胶质瘤决定簇（“ gdm”），预测生存时间的方法，诊断神经胶质瘤样肿瘤严重程度的方法和用途

页面导航
  • 摘要
  • 著录项
  • 相似文献

摘要

METHOD FOR TREATING A GLIOMA TYPE, METHODS OF PROGNOSIS AND / OR DIAGNOSIS OF GLIOMA, METHOD OF MONITORING OR DIAGNOSIS, METHOD OF INHIBITING THE GROWTH OR GROWTH OF A TUMOR OF THE TYPE OF GLYOMA, THERAPEUT, EXPRESSION OF GLIOMA DETERMINANT MARKERS ("GDM") OF PN, PROLIFED MONTHS, METHOD FOR PROGNOSING SURVIVAL TIME, METHOD FOR DIAGNOSING THE SEVERITY OF A TYPE OF THE GLYOMA TYPE AND USE. The invention in general provides a method of monitoring diagnosis, prognosis and treatment of glioma. Specifically, the invention establishes three (3) prognostic subcies of glioma, which are differently associated with the activation of the akt and Notch signaling pathways. Tumor showing markers of neural or proneural PN lineage (including elements of the notch pathway) shows longest patient survival mean, while the two remaining tumor markers Prolif and Mes are associated with short survival. Tumors classified in this way can also be treated with PN Prolif or Mes therapies that correspond to subclassification, in combination with anti-mitotic agents, anti-angiogenic agents, Akt antagonists and neural differentiation agents. Alternatively, the invention also establishes a method of prognosis and diagnosis of glioma with a double gene model based on the levels of expression of PTEN and DLL3.
机译：治疗胶质瘤类型的方法，胶质瘤的预后和/或诊断方法，监测或诊断的方法，抑制胶质瘤类型，肿瘤的生长或生长的方法，胶质瘤决定标记（“胶质”的表达） （PN），已修正的月份，生存时间的预测方法，诊断胶体类型的严重性及其用途的诊断方法。总体上，本发明提供了一种监测神经胶质瘤的诊断，预后和治疗的方法。具体而言，本发明建立了三（3）个神经胶质瘤的预后亚型，它们与akt和Notch信号通路的激活不同地相关。肿瘤显示神经或前神经PN谱系的标志物（包括刻槽通路的元素）显示出最长的患者生存平均值，而剩下的两个肿瘤标志物Prolif和Mes与生存期短有关。以这种方式分类的肿瘤也可以与抗有丝分裂剂，抗血管生成剂，Akt拮抗剂和神经分化剂联合使用对应于亚类的PN Prolif或Mes疗法进行治疗。或者，本发明还基于PTEN和DLL3的表达水平，建立了具有双基因模型的神经胶质瘤的预后和诊断方法。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号