首页> 外国专利> compound, pharmaceutical composition; use of the compound for the manufacture of a medicament for treating irritable bowel syndrome, treating pain or painful syndromes, treating urinary incontinence, treating depression, fibromyalgia, anxiety, panic disorder, agorophobia, pre-traumatic stress disorder, pre-dysphoric disorder menstrual disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, gilles de la tourette syndrome, vasomotor discharge, cocaine addiction, sexual dysfunction, personality threshold disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, shy drager syndrome, raynaud syndrome, parkinson's disease, and epilepsy, method of preparing a compound of structure (a), and Method of preparing a compound of structure (b)

compound, pharmaceutical composition; use of the compound for the manufacture of a medicament for treating irritable bowel syndrome, treating pain or painful syndromes, treating urinary incontinence, treating depression, fibromyalgia, anxiety, panic disorder, agorophobia, pre-traumatic stress disorder, pre-dysphoric disorder menstrual disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, gilles de la tourette syndrome, vasomotor discharge, cocaine addiction, sexual dysfunction, personality threshold disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, shy drager syndrome, raynaud syndrome, parkinson's disease, and epilepsy, method of preparing a compound of structure (a), and Method of preparing a compound of structure (b)

机译:化合物,药物组合物;该化合物在制备用于治疗肠易激综合症,治疗疼痛或疼痛综合症,治疗尿失禁,治疗抑郁症,纤维肌痛,焦虑症,恐慌症,广场恐惧症,创伤前应激障碍,烦躁不安症,月经失调的药物中的用途,注意力缺陷障碍,强迫症,社交焦虑症,广泛性焦虑症,自闭症,精神分裂症,肥胖症,神经性厌食症,神经性贪食症,抽动秽语综合征,血管舒缩放电,可卡因成瘾,性功能障碍,人格阈障碍,纤维肌痛综合征,糖尿病性神经性疼痛,慢性疲劳综合症,害羞药物综合征,雷诺氏综合症,帕金森氏病和癫痫病,结构式(a)的化合物的制备方法和结构式(b)的化合物的制备方法

摘要

COMPOUND, PHARMACEUTICAL COMPOSITION; USE OF COMPOUND FOR MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT IRRITABLE GUT SYNDROME, TREAT PAIN OR PAINFUL SYNDROMES, TREAT DEPRESSION, FIBROMIALGIA, ANXIETY, DISTRIBUTIC DISTRHESIS, DISTRIBUTORY AGE MENSTRUAL, DISTRICT OF ATTENTION DEFICIT, OBSESSIVE COMPULSIVE DISORDER, SOCIAL ANXIETY DISORDER, GENERALIZED ANXIETY DISTORBUS, AUTISM, SCHIZOPHRENIA, NERVOSA NERGOSA, NERVOUS DEROSIA, GERDOSA Sexual Dysfunction, Personality Threshold Disorder, Fibromyalgia Syndrome, Diabetic Neuropathic Pain, Chronic Fatigue Syndrome, SHY DRAGER SYNDROME, EYPREP DEPRED DEPRED A SYNDROME, SYNDROME OF THE CRAPPED EYES METHOD OF PREPARING A FRAME COMPOUND (B). Highly selective dual serotonin and norepinephrine reuptake inhibitors are provided. These compounds have a low profile of side effects and are useful in compositions and products for use in the treatment of a variety of conditions including depression, fibromyalgia, anxiety, panic disorder, agorophobia, posttraumatic stress disorder, premenstrual dysphoric disorder. , attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, Gilles de la Tourette's syndrome, vasomotor discharge, cocaine and alcohol addiction, dysfunction personality disorder, personality threshold disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, Shy Drager syndrome, Raynaud's syndrome, Parkinson's disease, and epilepsy.
机译:化合物,药物成分;使用化合物制造药物来治疗肠易激综合症,疼痛或疼痛性综合症,抑郁症,纤维化,焦虑症,分布不均,分布年龄偏痛,注意力不集中,注意力不集中,畸形肌,自闭症,精神分裂症,神经痛,神经衰弱,GERDOSA性功能障碍,人际阈值障碍,纤维肌痛综合征,糖尿病性神经性疼痛,慢性疲劳综合症,慢性疲劳综合征,急速发作的急速呼吸道疾病框架化合物(B)。提供了高度选择性的5-羟色胺和去甲肾上腺素再摄取抑制剂。这些化合物的副作用低,可用于组合物和产品中,用于治疗各种病症,包括抑郁症,纤维肌痛,焦虑症,恐慌症,恐惧症,创伤后应激障碍,经前烦躁不安。 ,注意缺陷障碍,强迫症,社交焦虑症,广泛性焦虑症,自闭症,精神分裂症,肥胖症,神经性厌食症,神经性贪食症,吉尔斯·德·图雷特综合症,血管舒缩,可卡因和酒精成瘾,人格障碍,纤维肌痛综合征,糖尿病性神经性疼痛,慢性疲劳综合征,害羞的Drager综合征,Raynaud综合征,帕金森氏病和癫痫病。

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