首页> 外国专利> Nonalcoholic steatohepatitis model rodent and fatty liver model rodent

Nonalcoholic steatohepatitis model rodent and fatty liver model rodent

机译:非酒精性脂肪性肝炎模型啮齿动物和脂肪肝模型啮齿动物

摘要

Disclosed is a nonhuman animal showing the symptoms of human nonalcoholic steatohepatitis which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal and then transplanting human hepatocytes that are propagated in the body of the chimeric nonhuman animal into an immunodeficient hepatopathic nonhuman animal of the same species as the immunodeficient hepatopathic nonhuman animal described above, as well as a nonhuman animal showing the symptoms of human fatty liver which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal.
机译:公开了一种非人动物,其表现出人非酒精性脂肪性肝炎的症状,其是通过将人肝细胞移植到免疫缺陷的肝病性非人动物中产生嵌合非人动物,然后将在嵌合非人动物体内繁殖的人肝细胞移植到免疫缺陷中而获得的。与上述免疫缺陷性肝病非人类动物具有相同物种的肝病性非人类动物,以及显示人脂肪肝症状的非人类动物,其是通过将人肝细胞移植到免疫缺陷性肝病非人类动物中产生嵌合非人类动物而获得的。

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