首页> 外国专利> VLA-4 AS A BIOMARKER FOR PROGNOSIS AND TARGET FOR THERAPY IN DUCHENNE MUSCULAR DYSTROPHY

VLA-4 AS A BIOMARKER FOR PROGNOSIS AND TARGET FOR THERAPY IN DUCHENNE MUSCULAR DYSTROPHY

机译：VLA-4作为杜氏肌肉营养不良预后和治疗靶标的生物标志物

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摘要

The invention relates to methods for the treatment of Duchenne muscular dystrophy and to methods for determining the prognosis of a subject affected with Duchenne Muscular Dystrophy. More particularly, the present invention relates to a VLA-4 antagonist for use in the treatment of Duchenne Muscular Dystrophy. The present invention also relates to a method for determining the prognosis of a subject affected with Duchenne Muscular Dystrophy wherein said method comprising a step consisting of determining the level of VLA-4 high T cells in a blood sample obtained from said subject.

机译：本发明涉及治疗杜氏肌营养不良症的方法和确定患有杜氏肌营养不良症的受试者的预后的方法。更具体地，本发明涉及用于治疗杜兴氏肌营养不良症的VLA-4拮抗剂。本发明还涉及确定患有杜氏肌营养不良症的受试者的预后的方法，其中所述方法包括确定从所述受试者获得的血液样品中的VLA-4高T细胞水平的步骤。

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公开/公告号US2012258093A1

专利类型
公开/公告日2012-10-11

原文格式PDF
申请/专利权人 GILLIAN BUTLER-BROWNE;SUSE DAYSE SILVA-BARBOSA;WILSON SAVINO;ALEXANDRA PRUFER DE QUEIROZ CAMPOS ARAUJO;FERNANDA PINTO-MARIZ;LUCIANA RODRIGUES CARVALHO;THOMAS VOIT;
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申请/专利号US201013390236
发明设计人 GILLIAN BUTLER-BROWNE;SUSE DAYSE SILVA-BARBOSA;WILSON SAVINO;ALEXANDRA PRUFER DE QUEIROZ CAMPOS ARAUJO;FERNANDA PINTO-MARIZ;LUCIANA RODRIGUES CARVALHO;THOMAS VOIT;
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申请日2010-08-19
分类号G01N21/64;C12Q1/68;A61K31/713;G01N33/566;A61K39/395;A61K31/7088;C40B30/04;A61K38/02;
国家 US
入库时间 2022-08-21 17:35:16

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