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Targeted recombinant non-human mammal with human FAD presenilin mutation and reproductive progeny
Targeted recombinant non-human mammal with human FAD presenilin mutation and reproductive progeny
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机译：具有人FAD早老素突变和生殖后代的靶向重组非人哺乳动物
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摘要
The present invention provides a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD presenilin-1 (PS-1) gene, a human FAD Swedish mutation, and a humanized A beta mutation, and generational offspring thereof and a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD PS-1 gene and a human Swedish APP695 mutation, and generational offspring thereof, as well as methods of identifying compounds useful in treating Alzheimer's disease, and to methods of treating Alzheimer's disease.
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