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Method for predicting cervical lymph node metastasis of oral cancer and diagnostic kit used for the prediction

机译:口腔癌颈淋巴结转移的预测方法及用于预测的诊断试剂盒

摘要

A method for objectively predicting possibility of metastasis to a cervical lymph node in an early stage for an individual case diagnosed as an oral cavity cancer, and a diagnosis kit to be used in the prediction are provided. The method includes a step of assaying expression amounts of metastasis prediction genes in which the expression amounts are changed between a metastasis group and a non-metastasis group, with respect to a sample collected from a primary legion of the oral cavity cancer. Further, the method includes a step of predicting the possibility of the metastasis by comparing the expression amounts of the metastasis gene group with the expression amounts of the metastasis prediction genes in a metastasis group and/or a non-metastasis group. Herein, the metastasis prediction gene group includes two genes MSR1 (NM_138716.1) and RET (M31213.1).
机译:本发明提供了一种用于客观地诊断出被诊断为口腔癌的个体在早期阶段转移到颈淋巴结的可能性的方法,以及在该预测中使用的诊断试剂盒。该方法包括相对于从口腔癌的原发灶收集的样品测定转移预测基因的表达量的步骤,其中转移量在转移组和非转移组之间改变。此外,该方法包括通过比较转移基因组的表达量与转移组和/或非转移组中转移预测基因的表达量来预测转移可能性的步骤。在此,转移预测基因组包括两个基因MSR1(NM_138716.1)和RET(M31213.1)。

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